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Lifestyle Changes and Supplements

The goal of this study was to compare the lipid-lowering effects of an alternative regimen (lifestyle changes, red yeast rice, and fish oil) with a standard dose of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin). The randomized, controlled study concluded that lifestyle changes combined with ingestion of Red Yeast Rice and fish oil is a promising alternative approach to the standard therapy of Simvastatin.

There was a statistically significant reduction in LDL-C levels in both the AG (-42.4%±15%) (P<.001) and the simvastatin group (-39.6%±20%) (P<.001). No significant differences were noted between groups. The AG also demonstrated significant reductions in triglycerides (-29% vs -9.3%; 95% confidence interval, -61 to -11.7; P=.003) and weight (-5.5% vs -0.4%; 95% confidence interval, -5.5 to -3.4; P<.001) compared with the simvastatin group.

David J. Becker, Ram Y. Gordon, Patti B. Morris, Jacqueline Yorko, Y. Jerold Gordon, Mingyao Li, Nayyar Iqbal. Simvastatin vs Therapeutic Lifestyle Changes and Supplements: Randomized Primary Prevention Trial.

Mayo Clinic Proceedings - July 2008 (Vol. 83, Issue 7, Pages 758-764, DOI: 10.4065/83.7.758)