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Red Yeast Rice and Dyslipidemia

A randomized, controlled trial through a community based cardiology practice found that Red Yeast Rice and therapeutic lifestyle change decrease LDL cholesterol level without increasing CPK or pain levels and may be a treatment option for dyslipidemic patients who cannot tolerate statin therapy. Below are the results and a link to the original article.

In the red yeast rice group, LDL cholesterol decreased by 1.11 mmol/L (43 mg/dL) from baseline at week 12 and by 0.90 mmol/L (35 mg/dL) at week 24. In the placebo group, LDL cholesterol decreased by 0.28 mmol/L (11 mg/dL) at week 12 and by 0.39 mmol/L (15 mg/dL) at week 24. Low-density lipoprotein cholesterol level was significantly lower in the red yeast rice group than in the placebo group at both weeks 12 (PÂ < 0.001) and 24 (PÂ = 0.011). Significant treatment effects were also observed for total cholesterol level at weeks 12 (PÂ < 0.001) and 24 (PÂ = 0.016). Levels of HDL cholesterol, triglyceride, liver enzyme, or CPK; weight loss; and pain severity scores did not significantly differ between groups at either week 12 or week 24.

Source:
Annals of Internal Medicine. 2009 Jun;150(12):830-839. http://annals.org/article.aspx?articleid=744558.