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Tag Archives: cholesterol and heart disease

  • Is One Plasma Lipid More Likely To Indicate CVD Risk?

    While a high low-density lipoprotein cholesterol (LDL-C) number is widely known to be associated with increased risk of cardiovascular disease (CVD), are there other combinations of LDL-C, triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) that point to an increased chance of heart disease?

    To find out, researchers at Boston University analyzed 20+ years of lipid data from 3,501 participants in the Framingham Offspring Study. All were CVD free at baseline. Participants were placed into eight groups depending on their beginning blood lipid values, and the groups compared to rate their ability to predict CVD risk. The results appeared in the December 2014 issue of the American Heart Journal.

    The study revealed that all combinations of high LDL-C, low HDL-C, and high TG were associated with CVD risk. Only isolated high TG was not independently associated with increased CVD risk.

    According to the study, the group most closely associated with CVD risk exhibited low HDL-C by itself, or in combination with high LDL-C and/or high TG.

    On the other end of the spectrum, high LDL-C alone was associated with only a marginally increased CVD risk. However, the group risk was further increased by the presence of either a low HDL-C or a high TG concentration.

    According to the team, low HDL-C and high TG levels commonly are found together, and are often related to obesity, insulin resistance, and metabolic syndrome.

    The study may have clinical implications. As the team reported, although high LDL-C may be the only risk factor for CVD that can be changed, it’s important to recognize that people with low HDL-C and high TG, in combination with high LDL-C and/or low HDL-C, have a worse prognosis in terms of the relative risk of CVD..

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